Genomics

Dataset Information

39

Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins


ABSTRACT: We characterized the mechanisms that allow yeast cells to survive under conditions of thiol peroxidase deficiency. Two thiol peroxidase null yeast (delta8) strains independently acquired a second copy of chromosome XI and increased expression of genes encoded by it. Delta-8 strains were compared to the Wt-M11 strain, which is characterized by duplication of chr-XI. Overall design: Examination of thiol peroxidase-deficient yeast strains.

INSTRUMENT(S): Illumina HiSeq 2000 (Saccharomyces cerevisiae)

SUBMITTER: Inge Seim 

PROVIDER: GSE70036 | GEO | 2015-10-10

SECONDARY ACCESSION(S): PRJNA287520

REPOSITORIES: GEO

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Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.

Kaya Alaattin A   Gerashchenko Maxim V MV   Seim Inge I   Labarre Jean J   Toledano Michel B MB   Gladyshev Vadim N VN  

Proceedings of the National Academy of Sciences of the United States of America 20150810 34


Aerobic respiration is a fundamental energy-generating process; however, there is cost associated with living in an oxygen-rich environment, because partially reduced oxygen species can damage cellular components. Organisms evolved enzymes that alleviate this damage and protect the intracellular milieu, most notably thiol peroxidases, which are abundant and conserved enzymes that mediate hydrogen peroxide signaling and act as the first line of defense against oxidants in nearly all living organi  ...[more]

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