Transcriptomics,Genomics

Dataset Information

39

MicroRNA profiles for lymph node metastasis in T1-stage colorectal cancers.


ABSTRACT: If we can more accurately predict the likelihood of regional lymph node metastasis (LNM) for endoscopically resected T1-stage colorectal cancers (CRC), the number of unnecessary additional surgeries can be reduced. We aimed of identify miRNA markers that can predict LNM-positive tumors among T1-stage CRCs and we also developed a miRNA classifier set for facilitating the accuracy and applicability. Overall design: Tumor cell rich areas (>70% of tumor cells) were selected and microdissected under a microscope. Total RNA was extracted using the RecoverAll™ Total Nucleic Acid Isolation Kit for FFPE. Then, we examined global miRNA expression profiles from 16 T1-stage CRCs (7 LNM-positive and 9 LNM- negative tumors) using miRNA-array analysis.

INSTRUMENT(S): Agilent-031181 Unrestricted_Human_miRNA_V16.0_Microarray 030840 (Feature Number version)

SUBMITTER: SeungHyun Jung  

PROVIDER: GSE70574 | GEO | 2015-09-30

SECONDARY ACCESSION(S): PRJNA289055

REPOSITORIES: GEO

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