Dataset Information


Methylome Analysis of Esophageal Squamous Cell Carcinoma by using Next Generation Sequencing

ABSTRACT: We obtained methylome profiling (MeDIP-seq) of esophageal squamous cell carcinoma (ESCC) and normal tissue specimens by using next generation sequencing. Overall design: Comparison of DNA methylation pfofiles between ESCC and normal mucosa.

INSTRUMENT(S): AB 5500 Genetic Analyzer (Homo sapiens)

SUBMITTER: noriko nishi 

PROVIDER: GSE71410 | GEO | 2018-02-13


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DNA hypermethyation and silencing of PITX1 correlated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinoma.

Otsubo Takeshi T   Yamada Kazuhiko K   Hagiwara Teruki T   Oshima Kenshiro K   Iida Kei K   Nishikata Koro K   Toyoda Tetsuro T   Igari Toru T   Nohara Kyoko K   Yamashita Satoshi S   Hattori Masahira M   Dohi Taeko T   Kawamura Yuki I YI  

Oncotarget 20170928 48

Esophageal squamous cell carcinoma (ESCC) is associated with the accumulation of genetic and epigenetic changes in the background mucosa. Dysregulated DNA methylation is known to lead to the inactivation of tumor suppressor genes and the activation of oncogenes. To identify the genes whose expression is perturbed by abnormal DNA methylation in ESCC, integrative transcriptomics by serial analysis of gene expression (SAGE) and methylome sequencing by methyl-DNA immunoprecipitation (MeDIP) analysis  ...[more]

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