Dataset Information


Evolution of insect hindwing morphology: A comparative genomic analysis of targets of Hox protein Ultrabithorax

ABSTRACT: To gain insights into the species-specific events downstream of Ubx, we identified direct targets of Ubx from Apis by ChIP-seq and compared them with those of Drosophila at the level of both their function and regulation. While the majority of the targets are species-specific, the ontological distribution of all targets was similar amongst the two species. Interestingly, although considerable number of wing-patterning genes are retained as targets of Ubx over the past 300 millions years, many of them are differentially expressed only between wing and haltere in Drosophila and not between forewing and hindwing in Apis . Detailed bioinfomatics analysis and and experimental validation of enhancer sequences suggest that acquisition of binding sites for additional transcription factors without altering binding per se of Ubx could also contribute to the diversity in Ubx function.

ORGANISM(S): Apis mellifera

PROVIDER: GSE71847 | GEO | 2016/08/31



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