Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Acute loss of TET function results in aggressive myeloid cancer in mice

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE72630 | GEO | 2015/11/26

SECONDARY ACCESSION(S): PRJNA294512

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Acute loss of TET function results in aggressive myeloid cancer in mice

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-11-26 | E-GEOD-72630 | biostudies-arrayexpress

Acute loss of TET function results in aggressive myeloid cancer in mice.

Project description: Not available

| S-EPMC4674670 | biostudies-literature

Acute loss of TET function results in aggressive myeloid cancer in mice [WGBS]

Project description:To evaluate the DNA methylation in LSK cells from the bone marrow of wildtype or Tet2/3 DKO mice. In order to address the impact of the loss of Tet2/3 proteins in DNA methylation in LSK cells, we compared by WGBS the methylome of wild and, Tet2/3 DKO LSK cells in bone marrow.

2015-11-26 | E-GEOD-72629 | biostudies-arrayexpress

Acute loss of TET function results in aggressive myeloid cancer in mice [WGBS]

Project description:To evaluate the DNA methylation in LSK cells from the bone marrow of wildtype or Tet2/3 DKO mice.

2015-11-26 | GSE72629 | GEO

Acute loss of TET function results in aggressive myeloid cancer in mice [RNA-Seq]

Project description:TET-family dioxygenases oxidize 5-methylcytosine (5mC) in DNA, and exert tumor suppressor activity in many types of cancers. Even in the absence of TET coding region mutations, TET loss-of-function is strongly associated with cancer. We show that acute elimination of TET function induces the rapid development of an aggressive, fully-penetrant and cell-autonomous myeloid leukemia in mice, pointing to a causative role for TET-loss-of-function in this myeloid malignancy. Phenotypic and transcriptional profiling showed aberrant differentiation of hematopoietic stem/ progenitor cells, impaired erythroid and lymphoid differentiation and strong skewing to the myeloid lineage, with only a mild relation to changes in DNA modification. We also observed progressive accumulation of DNA damage and strong impairment of DNA break repair, suggesting a key role for TET proteins in maintaining genomic integrity.

2015-11-26 | GSE72628 | GEO

Acute loss of TET function results in aggressive myeloid cancer in mice

Project description:Acute loss of TET function results in aggressive myeloid cancer in mice

| PRJNA294512 | ENA

Expression and prognosis analysis of TET family in acute myeloid leukemia.

Project description: Not available

| S-EPMC7138570 | biostudies-literature

Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-04-17 | GSE222726 | GEO

Loss of Rab27 function results in abnormal lung epithelium structure in mice.

Project description: Not available