Transcriptomics,Genomics

Dataset Information

31

Expression data for analysis of genes affected by PAX3-FOXO1 in alveolar rhabdomyosarcoma cell line Rh4


ABSTRACT: PAX3-FOXO1 is a fusion transcription factor characteristic for the majority of alveolar rhabdomyosarcoma tumors. It is the main oncogenic driver and deregulates expression of PAX3 target genes. The PAX3-FOXO1 target gene signature was determined in the Rh4 alveolar rhabdomyosarcoma cell line. Overall design: Rh4 cells were transfected with siRNA directed against PAX3-FOXO1 or scrambled control. RNA was isolated from these cells after 24, 48 and 72 h.

INSTRUMENT(S): [HG-U133A] Affymetrix Human Genome U133A Array

SUBMITTER: Beat Schäfer  

PROVIDER: GSE73483 | GEO | 2015-09-29

SECONDARY ACCESSION(S): PRJNA297143

REPOSITORIES: GEO

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Publications

Comparative expression profiling identifies an in vivo target gene signature with TFAP2B as a mediator of the survival function of PAX3/FKHR.

Ebauer M M   Wachtel M M   Niggli F K FK   Schäfer B W BW  

Oncogene 20070521 51


The chromosomal translocation t(2;13), characteristic for the aggressive childhood cancer alveolar rhabdomyosarcoma (aRMS), generates the chimeric transcription factor PAX3/FKHR with a well known oncogenic role. However, the molecular mechanisms mediating essential pathophysiological functions remain poorly defined. Here, we used comparative expression profiling of PAX3/FKHR silencing in vitro and PAX3/FKHR-specific gene signatures in vivo to identify physiologically important target genes. Here  ...[more]

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