Transcriptomics

Dataset Information

23

Expression data from Hfe-deficient liver and duodenum in mouse strains with differing susceptibilities to iron loading


ABSTRACT: Hfe disruption in the mouse leads to experimental hemochromatosis by a mechanism which remains elusive. Evidence for at least five modifier genes has been obtained. These account for the higher iron load of Hfe-deficient D2 mice compared to B6 mice. Gene expression profling was used to clarify the mechanism of Hfe action and to identify potential modifier genes. Keywords: response to genetic modification Overall design: Liver and duodenum were obtained from wild-type and Hfe-deficient B6 and D2 mice (three mice per strain/genotype combination).

REANALYSED by: GSE119128

INSTRUMENT(S): [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

ORGANISM(S): Mus musculus  

SUBMITTER: Marie-Paule Roth  

PROVIDER: GSE7357 | GEO | 2008-03-22

SECONDARY ACCESSION(S): PRJNA100429

REPOSITORIES: GEO

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