Genomics

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Downregulation of LATS kinases alters p53 to promote cell migration


ABSTRACT: p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-?B subunit. Moreover, it partly shifts p53’s conformation and transcriptional output towards a state resembling cancer-associated p53 mutants, and endow p53 with the ability to promote cell migration. Notably, LATS1 and LATS2 are frequently downregulated in breast cancer; we propose that such downregulation might benefit cancer by converting p53 from a tumor suppressor into a tumor facilitator.

ORGANISM(S): Homo sapiens

PROVIDER: GSE74493 | GEO | 2015/12/11

SECONDARY ACCESSION(S): PRJNA300555

REPOSITORIES: GEO

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