Dataset Information


Global changes in Mycoplasma gallisepticum Phase-Variable Lipoprotein Gene vlhA Expression during in vivo infection of the natural chicken host

ABSTRACT: The goals of this study were to assess the vlhA gene expression of M. gallisepticum at various time over the course of early infection in the chicken host, and in in-vitro culture before innoculation and after recovery Overall design: Assessment of vlhA gene expression from broth grown input cultures (n=1), M. gallisepticum collected directly from the trachea over 7 days (n=5 per day), and M. gallisepticum recovered and passaged in-vitro 5 or 10 times (n=2 per passage)

INSTRUMENT(S): Illumina HiSeq 2500 (Mycoplasma gallisepticum)

SUBMITTER: Edan Tulman  

PROVIDER: GSE75102 | GEO | 2015-11-18



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Global Changes in Mycoplasma gallisepticum Phase-Variable Lipoprotein Gene vlhA Expression during In Vivo Infection of the Natural Chicken Host.

Pflaum K K   Tulman E R ER   Beaudet J J   Liao X X   Geary S J SJ  

Infection and immunity 20151109 1

Mycoplasma gallisepticum is the primary etiologic agent of chronic respiratory disease in poultry, a disease largely affecting the respiratory tract and causing significant economic losses worldwide. Immunodominant proteins encoded by members of the variable lipoprotein and hemagglutinin (vlhA) gene family are thought to be important for mechanisms of M. gallisepticum-host interaction, pathogenesis, and immune evasion, but their exact role and the overall nature of their phase variation are unkn  ...[more]

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