Transcriptomics,Genomics

Dataset Information

22

Effect of loss of Jmjd1c on Hoxa9/Meis1 leukemia


ABSTRACT: Analysis of gene expression profile of Hoxa9/Meis1 leukemia cells 6 days after loss of Jmjd1c. Loss of Jmjd1c induces differentiation and Hoxa9/Meis1 leukemia cells. These results provide insight into the role of Jmjd1c in AML with elelvated expression of Hoxa9. Overall design: We used primary Jmjd1c f/f Hoxa9/Meis1 neo leukemia cells from three leukemic mice and delivered Cre-Tomato by retroviral infection. We sorted Tomato positive cells 6 days after Cre infection and subjected the samples to RNA-seq.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Noushin Farnoud  

PROVIDER: GSE75580 | GEO | 2016-06-09

SECONDARY ACCESSION(S): PRJNA304628

REPOSITORIES: GEO

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Publications


Self-renewal is a hallmark of both hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs); therefore, the identification of mechanisms that are required for LSC, but not HSC, function could provide therapeutic opportunities that are more effective and less toxic than current treatments. Here, we employed an in vivo shRNA screen and identified jumonji domain-containing protein JMJD1C as an important driver of MLL-AF9 leukemia. Using a conditional mouse model, we showed that loss of JMJD1C  ...[more]

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