Transcriptomics,Genomics

Dataset Information

45

African American esophageal squamous cell carcinoma expression profile reveals loss of detox networks


ABSTRACT: Esophageal carcinoma is the third most common gastrointestinal malignancy worldwide and is generally unresponsive to therapy. African Americans have an increased risk for esophageal squamous cell cancer (ESCC), the subtype that shows marked variation in geographic frequency. To identify key genes involved in ESC carcinogenesis in African Americans we conducted microarray expression profiling and found a significant dysregulation of genes encoding stress response and drug-metabolizing enzymes, mainly in NRF2 pathway. The involvement of NRF2 mediated oxidative damage represent a key step in the evolution of African American ESCC. Loss of activity of these enzymes would confer increased sensitivity of esophageal cells to xenobiotics, such as alcohol and tobacco smoke, and may account for the high incidence of ESCC in this ethnic group. The differential expression profile also indicates an inflammatory component and tissue regeneration in ESCC tumorigenesis. Together, these findings suggest a remarkable interplay of genetic and environmental factors in the pathogenesis of African American ESCC. Overall design: Fourteen paired Human biopsy specimens collected from African Americans diagnosed with Esophageal Squamous Cell Carcinoma (ESCC). Seven of the fourteen specimens represent ESCC while the remaining represent paired healthy tissue.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Kory R Johnson  

PROVIDER: GSE77861 | GEO | 2017-08-15

SECONDARY ACCESSION(S): PRJNA311754

REPOSITORIES: GEO

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Publications

African-American esophageal squamous cell carcinoma expression profile reveals dysregulation of stress response and detox networks.

Erkizan Hayriye Verda HV   Johnson Kory K   Ghimbovschi Svetlana S   Karkera Deepa D   Trachiotis Gregory G   Adib Houtan H   Hoffman Eric P EP   Wadleigh Robert G RG  

BMC cancer 20170619 1


BACKGROUND:Esophageal carcinoma is the third most common gastrointestinal malignancy worldwide and is largely unresponsive to therapy. African-Americans have an increased risk for esophageal squamous cell carcinoma (ESCC), the subtype that shows marked variation in geographic frequency. The molecular architecture of African-American ESCC is still poorly understood. It is unclear why African-American ESCC is more aggressive and the survival rate in these patients is worse than those of other ethn  ...[more]

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