Transcriptomics

Dataset Information

36

Transcriptome profiling in knock-in mouse models of Huntington's disease [Cortex_miRNA]


ABSTRACT: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric alterations. The mutation responsible for this disease is an abnormally expanded and unstable CAG repeat within the coding region of the gene encoding huntingtin (Htt). Knock-in mouse models of HD with human exon 1 containing expanded CAG repeats inserted in the murine huntingtin gene (Hdh) provide a genetic reconstruction of the human causative mutation within the mouse model. The goal of this study is RNA expression profiling by RNA sequencing (RNA-seq) in 6 and 10 months old knock-in mice with CAG lengths of 20, 50, 92, 140 along with littermate control wild-type animals Overall design: miRNA expression profiles were obtained via RNA-seq analysis performed on samples from the Cortex tissue of 6 and 10 months old knock-in mice with CAG lengths of 20, 50, 92, 140 along with littermate control wild-type animals.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Jeff Aaronson  

PROVIDER: GSE78791 | GEO |

SECONDARY ACCESSION(S): PRJNA313915

REPOSITORIES: GEO

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