Genomics

Dataset Information

172

Rev-erb alpha citrome in brown adipose tissue


ABSTRACT: We have reported that cold temperature challenge results in a dramatic decrease in levels of the transcriptional repressor, Rev-erb alpha. Performing Rev-erb alpha ChIP-seq on brown adipose from wildtype animals kept at thermoneutrality or cold-challenged (and using Rev-erb alpha KO brown adipose as a control), we were able to globally determine the genomic regions undergoing Rev-erb alpha-dependent de-repression. Overall design: Examination of Rev-erb alpha binding in brown adipose tissues under thermoneutral and cold-challenged conditions

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Hee-Woong Lim 

PROVIDER: GSE79167 | GEO | 2016-12-31

SECONDARY ACCESSION(S): PRJNA315096

REPOSITORIES: GEO

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Publications


Circadian oscillation of body temperature is a basic, evolutionarily conserved feature of mammalian biology. In addition, homeostatic pathways allow organisms to protect their core temperatures in response to cold exposure. However, the mechanism responsible for coordinating daily body temperature rhythm and adaptability to environmental challenges is unknown. Here we show that the nuclear receptor Rev-erbα (also known as Nr1d1), a powerful transcriptional repressor, links circadian and thermoge  ...[more]

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