Somatic PRDM2 c.4459delA mutations in colorectal cancers control histone methylation and tumor growth

ABSTRACT: Purpose: To identify the contribution of PRDM2 c.4459delA mutation to colorectal tumorigenesis Methods: We employed rAAV-mediated genome editing to correct somatic PRDM2 c.4459delA mutation in homozygously mutated cell line. Using next-generation sequencing we have compared transcriptional profile of parental and PRDM2-corrected cells. Results: RNA-seq profiling revealed that several hallmark cancer gene sets are affected by PRDM2 c.4459delA

ORGANISM(S): Homo sapiens

PROVIDER: GSE80033 | GEO | 2018/02/22

REPOSITORIES: GEO