Dataset Information


DGAT1 regulates retinol-dependent regulatory T cell generation and mediates autoimmune encephalomyelitis

ABSTRACT: This file contains gene microarray data from FACS purified mouse memory phenotype CD4+ T cells (CD44hiCD45RBloCD25-), which were isolated from lymph node and spinal cord tissues of mice with experimental autoimmune encephalomyelitis (EAE), a widely studied model of human multiple sclerosis (MS). Memory phenotype CD4+ T cells infiltrating the CNS during EAE expressed high levels of mRNA for Dgat1 encoding diacylglycerol-O-acyltransferase-1 (DGAT1). We studied the biology of DGAT1 in EAE models and in assays of T cell differentiation and function. Overall design: We analyzed transcript expression data from memory phenotype CD4+ T cells derived from draining lymph nodes (n=3) and spinal cords (n=3) of mice with acute symptomatic EAE .

INSTRUMENT(S): [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

SUBMITTER: Kareem Graham  

PROVIDER: GSE80978 | GEO | 2016-05-03



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