Transcriptomics,Genomics

Dataset Information

39

DGAT1 regulates retinol-dependent regulatory T cell generation and mediates autoimmune encephalomyelitis


ABSTRACT: This file contains gene microarray data from FACS purified mouse memory phenotype CD4+ T cells (CD44hiCD45RBloCD25-), which were isolated from lymph node and spinal cord tissues of mice with experimental autoimmune encephalomyelitis (EAE), a widely studied model of human multiple sclerosis (MS). Memory phenotype CD4+ T cells infiltrating the CNS during EAE expressed high levels of mRNA for Dgat1 encoding diacylglycerol-O-acyltransferase-1 (DGAT1). We studied the biology of DGAT1 in EAE models and in assays of T cell differentiation and function. Overall design: We analyzed transcript expression data from memory phenotype CD4+ T cells derived from draining lymph nodes (n=3) and spinal cords (n=3) of mice with acute symptomatic EAE .

INSTRUMENT(S): [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

SUBMITTER: Kareem Graham  

PROVIDER: GSE80978 | GEO | 2016-05-03

SECONDARY ACCESSION(S): PRJNA320220

REPOSITORIES: GEO

Similar Datasets

2014-02-20 | E-GEOD-49375 | ArrayExpress
2012-02-09 | GSE26267 | GEO
2012-02-09 | E-GEOD-26267 | ArrayExpress
2016-07-08 | PXD001011 | Pride
2019-01-02 | PXD011854 | Pride
| GSE92680 | GEO
2014-08-28 | E-GEOD-60847 | ArrayExpress
2015-08-18 | E-GEOD-36766 | ExpressionAtlas
2019-05-20 | E-MTAB-7311 | ArrayExpress
2015-04-02 | E-MTAB-2989 | ArrayExpress