Genomics

Dataset Information

37

Cord blood hematopoietic cells display altered DNA methylation patterns in preterm birth


ABSTRACT: Genome-wide DNA methylation was measured using the Illumina 450K array in T cells, monocytes, granulocytes and nucleated red blood cells (nRBCs) isolated from cord blood of term and extreme preterm (<31 weeks gestational age) individuals. 36 samples in total: 5 each of T cells, monocytes, granulocytes and nRBCs from term births; and 5 T cells, 4 monocytes, 4 nRBCs and 3 granulocytes from preterm births. Overall design: Bisulphite-converted DNA from 36 cord blood cell populations sorted by a FACS protocol formally excluding erythroid lineage-specific marker CD235 in white blood cells (T cells, monocytes, granulocytes and nucleated red blood cells collected from cord blood of 5 term and 5 preterm births) were hybridized to the Illumina Infinium HumanMethylation450 BeadChip.

INSTRUMENT(S): Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

SUBMITTER: Wendy Robinson  

PROVIDER: GSE82084 | GEO | 2017-04-21

SECONDARY ACCESSION(S): PRJNA323944

REPOSITORIES: GEO

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Publications

Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns.

de Goede Olivia M OM   Lavoie Pascal M PM   Robinson Wendy P WP  

Clinical epigenetics 20170420


Premature infants are highly vulnerable to infection. This is partly attributable to the preterm immune system, which differs from that of the term neonate in cell composition and function. Multiple studies have found differential DNA methylation (DNAm) between preterm and term infants' cord blood; however, interpretation of these studies is limited by the confounding factor of blood cell composition. This study evaluates the epigenetic impact of preterm birth in isolated hematopoietic cell popu  ...[more]

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