Transcriptomics,Genomics

Dataset Information

54

Pseudomonas aeruginosa PAO1 response to sphingomyelin


ABSTRACT: Analysis of Pseudomonas aeruginosa PAO1 treated with 200 µM sphingomyelin. Results provide insight into the response to sphingomyelin in P. aeruginosa. Overall design: P. aeruginosa PAO1 was cultured in the presence and absence of sphingomyelin. The orginal culture was divided into two parts. One was treated with 200 μM sphingomyelin and the other served as a control. The experiment was performed in tripricates.

INSTRUMENT(S): [Pae_G1a] Affymetrix Pseudomonas aeruginosa Array

SUBMITTER: Nozomu OKINO  

PROVIDER: GSE83078 | GEO | 2017-02-12

SECONDARY ACCESSION(S): PRJNA324695

REPOSITORIES: GEO

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Publications

Molecular mechanism for sphingosine-induced Pseudomonas ceramidase expression through the transcriptional regulator SphR.

Okino Nozomu N   Ito Makoto M  

Scientific reports 20161212


Pseudomonas aeruginosa, an opportunistic, but serious multidrug-resistant pathogen, secretes a ceramidase capable of cleaving the N-acyl linkage of ceramide to generate fatty acids and sphingosine. We previously reported that the secretion of P. aeruginosa ceramidase was induced by host-derived sphingolipids, through which phospholipase C-induced hemolysis was significantly enhanced. We herein investigated the gene(s) regulating sphingolipid-induced ceramidase expression and identified SphR, whi  ...[more]

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