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Gene expression analysis of total B, CD4+ T and epithelial cells in lacrimal glands from the NOD mouse model of Sjogren's syndrome

ABSTRACT: Despite being one of the most common rheumatologic diseases, there is still no disease-modifying drug for primary Sjögren’s syndrome (pSS). Advancing our knowledge of the target tissue has been limited by the low dimensionality of histology techniques and the small size of human salivary gland biopsies. The goal of this study was to characterize the gene expression profile of total B cells, CD4+ T cells and epithelial cells in the target tissue of the most commonly-used model of pSS (the NOD model of pSS characterized by severe dacryoadenitis developing in males between 8 and 16 weeks of age).

ORGANISM(S): Mus musculus

PROVIDER: GSE83113 | GEO | 2016/09/01

SECONDARY ACCESSION(S): PRJNA324806

REPOSITORIES: GEO

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Gene expression analysis of T cell subsets infiltrating lacrimal glands from the NOD mouse model of Sjögren's

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2020-07-09 | PXD016231 | Pride

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