Transcriptomics,Genomics

Dataset Information

141

Effects of fosfomycin on biofilm of a clinical Staphylococcus aureus isolated from osteoarticular infection by transcriptomal approach


ABSTRACT: The aim of the present study was to investigate the mechanisms by which fosfomycin restrains biofilm formation and affects a 24h-old biofilm of S. aureus. RNA sequencing (RNA-Seq) technology was used to compare the transcriptomes of S. aureus biofilms formed or treated with sublethal concentrations of fosfomycin. Overall design: Determination of the transcriptional profiling of S. aureus under 4 different experimental conditions. mRNA profiles were generated for bacteria under 4 hours-old biofilm formed with and without fosfomycin and 24 hours-old biofilm treated or not with fosfomycin for 24h, each in three biological replicates, by deep sequencing using Illumina HiSeq

INSTRUMENT(S): Illumina HiSeq 2500 (Staphylococcus aureus)

SUBMITTER: Christiane Forestier  

PROVIDER: GSE83269 | GEO | 2018-01-31

REPOSITORIES: GEO

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