Transcriptomics,Genomics

Dataset Information

56

Saccharomyces cerevisiae response to various stressors


ABSTRACT: Samples GSM206658-GSM206693: Acquired Stress resistance in S. cerevisiae: NaCl primary and H2O2 secondary Transcriptional timecourses of yeast cells exposed to 0.7M NaCl alone, 0.5mM H2O2 alone, or 0.5mM H2O2 following 0.7M NaCl, all compared to an unstressed sample. Repeated using msn2? strain. Samples GSM291156-GSM291196: Transcriptional response to stress in strains lacking MSN2 and/or MSN4 Transcriptional timecourses of yeast cells (WT, msn2?, msn4?, or msn2?msn4?) exposed to 0.7M NaCl for 45 minutes or 30-37°C Heat Shift for 15 min compared to an unstressed sample of the same strain. Keywords: Stress Response Overall design: Samples GSM206658-GSM206693: 2 condition timecourses; stressed cells vs unstressed cells; 2 biological replicates for the WT arrays, 1 biological replicate for the msn2? arrays; 1 replicate per array; samples were taken every 15 minutes for NaCl arrays and every 10 minutes for H2O2 arrays Samples GSM291156-GSM291196: 1 condition timecourses; stressed cells vs unstressed cells; 5-6 biological replicates for the WT arrays, 5 biological replicate for the msn2? arrays; 1 replicate per array; samples were taken at 45 minutes for NaCl arrays and at 15 minutes for Heat Shock arrays NOTE: Supplementary GPR files (GSM206663 and GSM291161) are identical. The normalization and the processing are almost identical, however, the submitter used a different cutoff internally for data that have been accepted or rejected between the two datasets.

INSTRUMENT(S): UWAPG Yeast 6K v1.0

SUBMITTER: David B Berry 

PROVIDER: GSE8335 | GEO | 2008-09-05

SECONDARY ACCESSION(S): PRJNA101333

REPOSITORIES: GEO

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Publications

Stress-activated genomic expression changes serve a preparative role for impending stress in yeast.

Berry David B DB   Gasch Audrey P AP  

Molecular biology of the cell 20080827 11


Yeast cells respond to stress by mediating condition-specific gene expression changes and by mounting a common response to many stresses, called the environmental stress response (ESR). Giaever et al. previously revealed poor correlation between genes whose expression changes in response to acute stress and genes required to survive that stress, raising question about the role of stress-activated gene expression. Here we show that gene expression changes triggered by a single dose of stress are  ...[more]

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