Genomics

Dataset Information

20

Array-CGH of human hepatocellular carcinoma


ABSTRACT: Comparison of normal versus tumor DNA (hepatocellular carcinoma). Whole-genome screening of DNA-copy number changes by array-based or matrix comparative genomic hybridization (aCGH). Tumor DNA labeled in Cy3 and pooled DNA of lymphocytes from healthy donors labeled in Cy5. Keywords: Genetic modification Overall design: DNA Copy number profiling of 67 human hepatocellular carcinomas of various etiologies

INSTRUMENT(S): DKFZ Homo sapiens 8k BAC-array

SUBMITTER: Christof Simon Schlaeger  

PROVIDER: GSE8351 | GEO | 2007-10-15

SECONDARY ACCESSION(S): PRJNA101365

REPOSITORIES: GEO

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Publications


UNLABELLED: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is characterized by aggressive tumor behavior coupled with poor prognosis. Various etiologies have been linked to HCC development, most prominently chronic hepatitis B and C virus infections as well as chronic alcohol consumption. In approximately 10% of HCCs, the etiology remains cryptic; however, recent epidemiological data suggest that most of these cryptogenic HCCs develop due to nonalcoholic steatohep  ...[more]