Dataset Information


Chromatin-enriched lncRNAs are cell type specifc enhancers for proximal genes

ABSTRACT: comparison of chromatin enriched RNA in different human cell lines Overall design: Biochemically fractionate nuclei to isolate chromatin-attached and soluble RNA populations

INSTRUMENT(S): Illumina HiSeq 2000 (Homo sapiens)

SUBMITTER: Alex Ruthenburg 

PROVIDER: GSE83531 | GEO | 2016-06-21



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Chromatin-enriched lncRNAs can act as cell-type specific activators of proximal gene transcription.

Werner Michael S MS   Sullivan Matthew A MA   Shah Rohan N RN   Nadadur Rangarajan D RD   Grzybowski Adrian T AT   Galat Vasiliy V   Moskowitz Ivan P IP   Ruthenburg Alexander J AJ  

Nature structural & molecular biology 20170619 7

We recently described a new class of long noncoding RNAs (lncRNAs) that are distinguished by especially tight chromatin association and whose presence is strongly correlated to expression of nearby genes. Here, we examine the cis-enhancer mechanism of this class of chromatin-enriched RNA (cheRNA) across multiple human cell lines. cheRNAs are largely cell type specific and provide the most reliable chromatin signature to predict cis-gene transcription in every human cell type examined. Targeted d  ...[more]