Genomics

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Nitric oxide-dependent changes in Schistosoma mansoni gene expression


ABSTRACT: Nitric oxide (NO) is a gaseous intercellular signaling molecule that also plays a role in host-parasite relations. NO acts rapidly, either via regulation of soluble guanylate cyclase, or by direct interactions with enzymes and other proteins, and has also been shown to have effects on gene expression. Here, we use SAGE (Serial Analysis of Gene Expression) to identify NO-responsive changes in gene expression in Schistosoma mansoni following a 3 hour exposure to sodium nitroprusside, an NO donor. Overall, these results indicate that NO does not rapidly induce large-scale changes in schistosome gene expression, but that expression of particular genes of interest appear to respond to NO. Keywords: Schistosoma, SAGE, NOS, nitric oxide, gene expression

ORGANISM(S): Schistosoma mansoni

PROVIDER: GSE8366 | GEO | 2007/07/04

SECONDARY ACCESSION(S): PRJNA101391

REPOSITORIES: GEO

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