Genomics

Dataset Information

17

A microRNA signature identifies four subtypes of triple-negative breast cancer and correlates miR-342-3p as a regulator of the lactate metabolic pathway through silencing the monocarboxylate transporter 1


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): [miRNA-2] Affymetrix Multispecies miRNA-2 Array

SUBMITTER: Sandra Lorena Romero-Cordoba  

PROVIDER: GSE86948 | GEO | 2018-08-17

SECONDARY ACCESSION(S): GSE86277 GSE86281 GSE86946 GSE86945 GSE86278

REPOSITORIES: GEO

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Publications

Loss of function of miR-342-3p results in MCT1 over-expression and contributes to oncogenic metabolic reprogramming in triple negative breast cancer.

Romero-Cordoba Sandra L SL   Rodriguez-Cuevas Sergio S   Bautista-Pina Veronica V   Maffuz-Aziz Antonio A   D'Ippolito Elvira E   Cosentino Giulia G   Baroni Sara S   Iorio Marilena V MV   Hidalgo-Miranda Alfredo A  

Scientific reports 20180816 1


Triple-negative breast cancer (TNBC) is a heterogeneous and aggressive neoplasia lacking the expression of hormonal receptors and human epidermal growth factor receptor-2. Accumulating evidence has highlighted the importance of miRNAs dysregulation in the establishment of cancer programs, but the functional role of many miRNAs remains unclear. The description of miRNAs roles might provide novel strategies for treatment. In the present work, an integrated analysis of miRNA transcriptional landsca  ...[more]

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