Transcriptomics,Genomics

Dataset Information

43

Low H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas


ABSTRACT: A subgroup of Posterior fossa ependymomas show reduced H3K27me3, global DNA hypomethylation, are more invasive, exhibit poor prognosis and epigenetically deregulated genes converge on radial glial factors, suggesting developing cerebellar radial glia as candidate cells-of-origin. Overall design: RNA-sequencingwas performed in 15 posterior fossa (PF) ependymoma samples. 11 samples show low H3K27me3 and designated PF_H3K27me3-ve; 4 samples show high H3K27me3 and designated PF_H3K27me3+ve

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Sriram Venneti  

PROVIDER: GSE89446 | GEO | 2016-11-23

SECONDARY ACCESSION(S): PRJNA352234

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE89446_mctp_rnaseq_counts.csv.gz Csv
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