Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)
SUBMITTER: Trudy Oliver
PROVIDER: GSE89660 | GEO | 2017-01-12
SECONDARY ACCESSION(S): PRJNA352851
REPOSITORIES: GEO
Mollaoglu Gurkan G Guthrie Matthew R MR Böhm Stefanie S Brägelmann Johannes J Can Ismail I Ballieu Paul M PM Marx Annika A George Julie J Heinen Christine C Chalishazar Milind D MD Cheng Haixia H Ireland Abbie S AS Denning Kendall E KE Mukhopadhyay Anandaroop A Vahrenkamp Jeffery M JM Berrett Kristofer C KC Mosbruger Timothy L TL Wang Jun J Kohan Jessica L JL Salama Mohamed E ME Witt Benjamin L BL Peifer Martin M Thomas Roman K RK Gertz Jason J Johnson Jane E JE Gazdar Adi F AF Wechsler-Reya Robert J RJ Sos Martin L ML Oliver Trudy G TG
Cancer cell 20170112 2
Loss of the tumor suppressors RB1 and TP53 and MYC amplification are frequent oncogenic events in small cell lung cancer (SCLC). We show that Myc expression cooperates with Rb1 and Trp53 loss in the mouse lung to promote aggressive, highly metastatic tumors, that are initially sensitive to chemotherapy followed by relapse, similar to human SCLC. Importantly, MYC drives a neuroendocrine-low "variant" subset of SCLC with high NEUROD1 expression corresponding to transcriptional profiles of human SC ...[more]