Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 20mGy/day gamma-rays for 400 days (Primary screening for 0mGyG family)

ABSTRACT: Transgenerational effects of continuous low dose-rate (LDR) gamma-ray irradiation have not been well studied. Recent advances in DNA technology enabled us to examine a whole genome at molecular level. Here we adopted one of these techniques called oligo-microarray comparative genome hybridization (CGH) and studied trans-generational effects on DNA copy number aberrations (CNAs). C57BL/6JNrs male mice were exposed to LDR gamma-rays (20 mGy/day) for 400 days (total dose: 8000 mGy) from 8 weeks of age. Progeny from 20 mGy/day irradiated mice had significantly higher frequencies of genomic aberrations than the progeny of non-irradiated mice. This study investigated the de novo mutation by comparing the parents and children using 25 irradiated male family and 25 non-irradiated male family. Grant: This study was performed under contract with the Aomori Prefectural Government, Japan.

ORGANISM(S): Mus musculus

PROVIDER: GSE89959 | GEO | 2016/11/17

SECONDARY ACCESSION(S): PRJNA354307

REPOSITORIES: GEO