Dataset Information


RNA-Seq of mESCs based on sex chromosome complement

ABSTRACT: RNA-Seq was performed on mESCs generated from F1 hybrids from reciprocal crosses of C57BL/6J and CAST/EiJ, denoted B and C hereafter; cell lines are designated as BC or CB, with the maternal line symbolized first Overall design: 3 XX and 3 XY lines were used from each cross as well as two XO lines for a total of 14 samples.

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Jozef Madzo  

PROVIDER: GSE90516 | GEO | 2017-09-15



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Sex chromosomes drive gene expression and regulatory dimorphisms in mouse embryonic stem cells.

Werner Rachael J RJ   Schultz Bryant M BM   Huhn Jacklyn M JM   Jelinek Jaroslav J   Madzo Jozef J   Engel Nora N  

Biology of sex differences 20170817 1

BACKGROUND:Pre-implantation embryos exhibit sexual dimorphisms in both primates and rodents. To determine whether these differences reflected sex-biased expression patterns, we generated transcriptome profiles for six 40,XX, six 40,XY, and two 39,X mouse embryonic stem (ES) cells by RNA sequencing. RESULTS:We found hundreds of coding and non-coding RNAs that were differentially expressed between male and female cells. Surprisingly, the majority of these were autosomal and included RNA encoding t  ...[more]

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