Dataset Information


Host genome surveillance for retrotransposons by transposon-derived proteins

ABSTRACT: ChIP-chip analyses of Abp1 and Cbh1 across the S. pombe genome. Keywords: ChIP-chip Overall design: Chromatin immunoprecipitated DNA recovered with antibody against FLAG-tagged protein from wild-type asynchronous growing fission yeast cells and whole cell extracts DNA were amplified by random priming and respectively labeled with Cy5 and Cy3. Labeled DNA samples were mixed and hybridized onto a 44k pombe Agilent oligo array. Data were processed using Agilent scanner and Feature Extraction software

INSTRUMENT(S): pombe 44K_v2

SUBMITTER: Shiv Grewal  

PROVIDER: GSE9056 | GEO | 2007-12-19



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Host genome surveillance for retrotransposons by transposon-derived proteins.

Cam Hugh P HP   Noma Ken-ichi K   Ebina Hirotaka H   Levin Henry L HL   Grewal Shiv I S SI  

Nature 20071219 7177

Transposable elements and their remnants constitute a substantial fraction of eukaryotic genomes. Host genomes have evolved defence mechanisms, including chromatin modifications and RNA interference, to regulate transposable elements. Here we describe a genome surveillance mechanism for retrotransposons by transposase-derived centromeric protein CENP-B homologues of the fission yeast Schizosaccharomyces pombe. CENP-B homologues of S. pombe localize at and recruit histone deacetylases to silence  ...[more]

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