Genomics

Dataset Information

19

Human embryonic stem cells: media/growth factor effects and differentiation timecourse


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Sentrix HumanRef-8 Expression BeadChip

SUBMITTER: Boris Greber  

PROVIDER: GSE9092 | GEO | 2008-03-12

SECONDARY ACCESSION(S): GSE9063 GSE9059 GSE9060 GSE9094PRJNA102611

REPOSITORIES: GEO

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Publications

Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity.

Greber Boris B   Lehrach Hans H   Adjaye James J  

Stem cells and development 20081201 6


The mechanisms controlling self-renewal versus lineage commitment in human embryonic stem (hES) cells are not well understood. Nonetheless, current knowledge suggests a crucial role for TGFbeta signaling in controlling these early fate decisions. We have investigated the effects of TGFbeta pathway activation and inhibition on gene expression in hES cells. Our data reveal that SMAD 2/3 signaling directly supports NANOG expression, while SMAD 1/5/8 activation moderately represses SOX2. In addition  ...[more]

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