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Effects of leptin on gene transcription of human epidermal keratinocytes

ABSTRACT: Subcutaneous fat adipocytes and dermal adipocytes produce leptin. Association of leptin with cutaneous would healing is known, however, the response of human epidermal keratinocytes to leptin has not unclear in a molecular level. In order to get biological insights on the role of leptin in epidermal physiology, the genome scale transcriptional response of normal human keratinocytes to leptin was investigated. Overall design: Normal human keratinocytes (NHKs) were treated with 10 ng/ml of leptin for 24 hours and harvested for total RNA extraction and hybridization on Affymetrix Human GeneChip 133 2.0 microarrays.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Minsoo Noh  

PROVIDER: GSE90979 | GEO | 2017-09-01



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Leptin regulates the pro-inflammatory response in human epidermal keratinocytes.

Lee Moonyoung M   Lee Eunyoung E   Jin Sun Hee SH   Ahn Sungjin S   Kim Sae On SO   Kim Jungmin J   Choi Dalwoong D   Lim Kyung-Min KM   Lee Seung-Taek ST   Noh Minsoo M  

Archives of dermatological research 20180221 4

The role of leptin in cutaneous wound healing process has been suggested in genetically obese mouse studies. However, the molecular and cellular effects of leptin on human epidermal keratinocytes are still unclear. In this study, the whole-genome-scale microarray analysis was performed to elucidate the effect of leptin on epidermal keratinocyte functions. In the leptin-treated normal human keratinocytes (NHKs), we identified the 151 upregulated and 53 downregulated differentially expressed genes  ...[more]

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