Transcriptomics

Dataset Information

24

Expression data from overexpression and knockdown of HOXC6 in LNCaP cells


ABSTRACT: The transcription factor HOXC6 is upregulated in human prostate cancer. SiRNA knockdown of HOXC6 induces apoptosis in LNCaP cells while upregulation rescued LNCaP cells from siRNA-induced apoptosis. We used microarrays to identify the genes whose expression underly the anti-apoptotic and proliferative effects of HOXC6 in LNCaP cells. Keywords: transient overexpression and knockdown Overall design: LNCaP cells were transiently transfected with a cocktail of 5 siRNAs to HOXC6 to a final concentration of 100nM, with a HOXC6 gene expression vector, or control siRNA and vector. Cells were collected a 48hours post-transfection

INSTRUMENT(S): [HG-U133A] Affymetrix Human Genome U133A Array

ORGANISM(S): Homo sapiens  

SUBMITTER: Colleen D McCabe 

PROVIDER: GSE9182 | GEO | 2008-07-01

SECONDARY ACCESSION(S): PRJNA102747

REPOSITORIES: GEO

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