Genomics

Dataset Information

160

Aire, guardian of immunological tolerance, binds to and activates super-enhancers [ATAC-seq]


ABSTRACT: ATAC-seq profiles of MECs and earskin fibroblasts Overall design: DAPI-CD45-Ly51loMHCIIhi MECs and DAPI-CD45-EpCAM-CD31-Ter-119-Sca-1+ earskin fibroblasts were single sorted and ATAC-seq profiling was perfomed.

INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)

SUBMITTER: CBDM Lab  

PROVIDER: GSE92594 | GEO | 2017-01-22

SECONDARY ACCESSION(S): PRJNA358090

REPOSITORIES: GEO

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Publications

The transcriptional regulator Aire binds to and activates super-enhancers.

Bansal Kushagra K   Yoshida Hideyuki H   Benoist Christophe C   Mathis Diane D  

Nature immunology 20170130 3


Aire is a transcription factor that controls T cell tolerance by inducing the expression of a large repertoire of genes specifically in thymic stromal cells. It interacts with scores of protein partners of diverse functional classes. We found that Aire and some of its partners, notably those implicated in the DNA-damage response, preferentially localized to and activated long chromatin stretches that were overloaded with transcriptional regulators, known as super-enhancers. We also identified to  ...[more]

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