Transcriptomics,Genomics

Dataset Information

40

Gene expression of Th17 cells from arthritic K/BxN mice


ABSTRACT: Th17 cells are involved in the development of many autoimmune diseases. However, recent studies have shown that in addition to the pathological Th17 effector cells located in inflammatory sites, there are also non-pathological Th17 cell types. We examined the expression of previously reported Th17 pathogenic (red font) and non-pathogenic (blue font) genes in Th17 cells isolated from a variety tissues by microarray. Overall design: Th17 cells marked by the expression of IL-17-eGFP were isolated from spleen, lung, and SI-LP of IL-17eGFP.K/BxN mice. We compared the fold differences of gene expression in SI-LP Th17 cells over those from spleen or lung for genes associated with pathogenic (red) and non-pathogenic (blue) Th17 cell signatures reported previously (35-37).

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Hsin-Jung Wu 

PROVIDER: GSE92860 | GEO | 2017-05-01

SECONDARY ACCESSION(S): PRJNA358665

REPOSITORIES: GEO

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Publications

Synthetic Retinoid AM80 Ameliorates Lung and Arthritic Autoimmune Responses by Inhibiting T Follicular Helper and Th17 Cell Responses.

Naskar Debdut D   Teng Fei F   Felix Krysta M KM   Bradley C Pierce CP   Wu Hsin-Jung Joyce HJ  

Journal of immunology (Baltimore, Md. : 1950) 20170127 5


Rheumatoid arthritis is an autoimmune disorder that affects the joints and other organs. Pulmonary complications contribute significantly to rheumatoid arthritis mortality. Retinoic acid and its synthetic compound AM80 play roles in immunoregulation but their effect on mucosal autoimmunity remains largely unknown. T follicular helper (Tfh) and Th17 cells are known to promote inflammation and autoantibody production. Using the K/BxN autoimmune arthritis model, we elucidate a novel mechanism where  ...[more]

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