Genomics

Dataset Information

0

Microarray Analyses of Otospheres Derived from the Cochlea in the Inner Ear Identify Putative Transcription Factors that Regulate the Characteristics of Otospheres


ABSTRACT: Stem/progenitor cells of the inner ear can be isolated as so-called otospheres from differentiated cells using a sphere forming assay. Although recent studies have demonstrated the characteristics of otospheres to some extent, most of the features of these cells are unknown. We describe the findings of transcriptome analyses with a cDNA microarray of otospheres derived from the cochleae of the inner ears of neonatal mice in order to clarify the gene expression profile of otic stem/progenitor cells. There were common transcription factors between otospheres and embryonic stem cells, which were supposed to be due to the stemness of otospheres. In comparison with the cochlear sensory epithelium, the otospheres shared characteristics with the cochlea, although several transcription factors specific for otospheres were identified. These transcription factors are expected to be essential for maintaining the characteristics of otospheres, and appear to be candidate genes that promote the direct conversion of cells into otic stem/progenitor cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE93055 | GEO | 2017/03/01

SECONDARY ACCESSION(S): PRJNA359749

REPOSITORIES: GEO

Similar Datasets

2017-03-09 | GSE69185 | GEO
2020-04-17 | GSE119545 | GEO
| E-GEOD-62512 | biostudies-arrayexpress
2005-01-01 | MODEL1305010000 | BioModels
2022-02-01 | GSE175998 | GEO
| E-MTAB-2336 | biostudies-arrayexpress
2022-12-12 | GSE185172 | GEO
2022-04-14 | GSE200629 | GEO
2009-04-02 | GSE15496 | GEO
2024-03-01 | GSE239362 | GEO