Dataset Information


DNA methylation profiling of first trimester villous cytotrophoblasts

ABSTRACT: Using the Illumina HumanMethylation450 BeadChip platform, we profiled the genome-wide DNA methylation of villous cytotrophoblasts samples isolated ex vivo from placental chorionic villi before they first come into contact with maternal blood (8-10 weeks of gestation, n = 9) and after (12-14 weeks of gestation, n = 10). Overall design: Bisulphite converted DNA was hybridized to Illumina HumanMethylation450 BeadChip arrays

INSTRUMENT(S): Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)

SUBMITTER: Akpeli V. Nordor 

PROVIDER: GSE93208 | GEO | 2017-01-07



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The early pregnancy placenta foreshadows DNA methylation alterations of solid tumors.

Nordor Akpéli V AV   Nehar-Belaid Djamel D   Richon Sophie S   Klatzmann David D   Bellet Dominique D   Dangles-Marie Virginie V   Fournier Thierry T   Aryee Martin J MJ  

Epigenetics 20170901 9

The placenta relies on phenotypes that are characteristic of cancer to successfully implant the embryo in the uterus during early pregnancy. Notably, it has to invade its host tissues, promote angiogenesis-while surviving hypoxia-, and escape the immune system. Similarities in DNA methylation patterns between the placenta and cancers suggest that common epigenetic mechanisms may be involved in regulating these behaviors. We show here that megabase-scale patterns of hypomethylation distinguish fi  ...[more]

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