Dataset Information


Differentially expressed genes after miRNA or siRNA transfection in human cancer cell lines (A-498, 786-O, A549, TE-8, PANC-1, SW1990, PC3 and PC3M)

ABSTRACT: To identify differentially expressed genes by anti cancer treatments (microRNAs or siRNAs) in human cancer, several cell lines ( renal cell carcinoma, lung adenocarcinoma, esophageal, pancreatic and prostate cancer) were subjected to Agilent whole genome microarrays. Overall design: Human cell lines (A-498, 786-O, A549, TE-8, PANC-1, SW1990, PC3 and PC3M) were treated with miRNAs (miR-10a-5p, miR-150-5p, miR-150-3p, miR-148a-5p, miR-148a-3p, miR-499a-5p, miR-455-3p and miR-455-5p), siRNAs (si-ANLN).

INSTRUMENT(S): Agilent-072363 SurePrint G3 Human GE v3 8x60K Microarray 039494 [Feature Number Version]

SUBMITTER: Naohiko Seki  

PROVIDER: GSE93290 | GEO | 2017-01-08



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Molecular pathogenesis of pancreatic ductal adenocarcinoma: Impact of passenger strand of pre-miR-148a on gene regulation.

Idichi Tetsuya T   Seki Naohiko N   Kurahara Hiroshi H   Fukuhisa Haruhi H   Toda Hiroko H   Shimonosono Masataka M   Okato Atsushi A   Arai Takayuki T   Kita Yoshiaki Y   Mataki Yuko Y   Kijima Yuko Y   Maemura Kosei K   Natsugoe Shoji S  

Cancer science 20180522 6

We previously used RNA sequencing to establish the microRNA (miRNA) expression signature of pancreatic ductal adenocarcinoma (PDAC). We found that both strands of pre-miR-148a (miR-148a-5p: the passenger strand and miR-148a-3p: the guide strand) were downregulated in cancer tissues. Ectopic expression of miR-148a-5p and miR-148a-3p significantly inhibited cancer cell migration and invasion, indicating that both strands of pre-miR-148a had tumor-suppressive roles in PDAC cells. In silico database  ...[more]

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