Transcriptomics,Genomics

Dataset Information

26

Gene expression profiling of prostate cancer


ABSTRACT: To better understand the molecular mechanism that underlay tumorigenesis and progression of prostate cancer (PCa), we studied the gene expression profiles of sixteen PCa compared to their matched normal tissues. Using Significance Analysis of Microarrays, we identified 53 genes differentially expressed that were more than 2 fold up- or down-regulated in at least 50 % of the tumors. Keywords: disease state analysis Overall design: Samples from 16 patients with prostate cancer were analyzed. The matched normal tissue from each patient was used as control. The control RNA (normal tissue) was labeled with Cy3 and the test RNA (prostate cancer tissue) with Cy5.

INSTRUMENT(S): CNIO H. sapiens 13.6k Oncochip 1

SUBMITTER: Jose M. Arencibia  

PROVIDER: GSE9347 | GEO | 2009-01-21

SECONDARY ACCESSION(S): PRJNA103037

REPOSITORIES: GEO

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Publications

Gene expression profiling reveals overexpression of TSPAN13 in prostate cancer.

Arencibia Jose M JM   Martín Susana S   Pérez-Rodríguez Francisco J FJ   Bonnin Ana A  

International journal of oncology 20090201 2


Prostate cancer is one of the most frequent malignancies in the Western world. The identification of additional molecular markers is needed to refine the diagnosis of prostate cancer and to develop more effective therapies. In order to identify molecular abnormalities involved in prostate cancer progression, we performed gene expression analysis of prostate cancer samples compared to matched normal tissue from the same patient using a cancer-related microarray. Amplified RNA was hybridized to a  ...[more]

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