Ontology highlight
ABSTRACT:
INSTRUMENT(S): [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
SUBMITTER: Tony Kwan
PROVIDER: GSE9372 | GEO | 2008-01-13
SECONDARY ACCESSION(S): PRJNA103079
REPOSITORIES: GEO
Kwan Tony T Benovoy David D Dias Christel C Gurd Scott S Provencher Cathy C Beaulieu Patrick P Hudson Thomas J TJ Sladek Rob R Majewski Jacek J
Nature genetics 20080113 2
We have performed a genome-wide analysis of common genetic variation controlling differential expression of transcript isoforms in the CEU HapMap population using a comprehensive exon tiling microarray covering 17,897 genes. We detected 324 genes with significant associations between flanking SNPs and transcript levels. Of these, 39% reflected changes in whole gene expression and 55% reflected transcript isoform changes such as splicing variants (exon skipping, alternative splice site use, intro ...[more]