Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000 (Drosophila melanogaster)
SUBMITTER: Karen Adelman
PROVIDER: GSE93763 | GEO | 2018-01-08
SECONDARY ACCESSION(S): PRJNA362313
REPOSITORIES: GEO
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Pai Athma A AA Henriques Telmo T McCue Kayla K Burkholder Adam A Adelman Karen K Burge Christopher B CB
eLife 20171227
Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reaction requires definition of splice sites, which are initially recognized in either intron-spanning ('intron definition') or exon-spanning ('exon definition') pairs. To understand how exon and intron length and splice site recognition mode impact splicing, we measured splicing rates genome-wide in Drosophila, using metabolic labeling/RNA sequencing and new mathematical models to estimate rates. We fou ...[more]