Genomics

Dataset Information

40

Genome-wide maps of metabolic labeled RNA in Drosophila S2 cells.


ABSTRACT: We report the application of ultrashort metabolic labeling of RNA for high-throughput profiling of RNA processing in Drosophila S2 cells. Overall design: Examination of 3 different labeling timepoints in Drosophila S2 cells.

INSTRUMENT(S): Illumina HiSeq 2000 (Drosophila melanogaster)

SUBMITTER: Karen Adelman  

PROVIDER: GSE93763 | GEO | 2018-01-08

SECONDARY ACCESSION(S): PRJNA362313

REPOSITORIES: GEO

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Publications

The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture.

Pai Athma A AA   Henriques Telmo T   McCue Kayla K   Burkholder Adam A   Adelman Karen K   Burge Christopher B CB  

eLife 20171227


Production of most eukaryotic mRNAs requires splicing of introns from pre-mRNA. The splicing reaction requires definition of splice sites, which are initially recognized in either intron-spanning ('intron definition') or exon-spanning ('exon definition') pairs. To understand how exon and intron length and splice site recognition mode impact splicing, we measured splicing rates genome-wide in Drosophila, using metabolic labeling/RNA sequencing and new mathematical models to estimate rates. We fou  ...[more]

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