Transcriptomics,Genomics

Dataset Information

144

Multifunctional glial support by Semper cells in the Drosophila retina


ABSTRACT: Using cell-restricted transcriptome analysis, here we show that Drosophila ommatidial cone (or Semper) cells are enriched for conserved glial regulators and effectors, including many characteristic of vertebrate retinal glia: Müller glia and astrocytes. Overall design: RNA-seq based analysis of Drosophila retinal cone cells (3 developmental stages) and photoreceptors. 1 sample per cell type - 4 total libraries sequenced.

REANALYSED by: GSE117217

INSTRUMENT(S): Illumina HiSeq 2500 (Drosophila melanogaster)

SUBMITTER: Tiffany Cook  

PROVIDER: GSE93782 | GEO | 2017-05-01

SECONDARY ACCESSION(S): PRJNA362350

REPOSITORIES: GEO

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Publications

Multifunctional glial support by Semper cells in the Drosophila retina.

Charlton-Perkins Mark A MA   Charlton-Perkins Mark A MA   Sendler Edward D ED   Buschbeck Elke K EK   Cook Tiffany A TA  

PLoS genetics 20170531 5


Glial cells play structural and functional roles central to the formation, activity and integrity of neurons throughout the nervous system. In the retina of vertebrates, the high energetic demand of photoreceptors is sustained in part by Müller glia, an intrinsic, atypical radial glia with features common to many glial subtypes. Accessory and support glial cells also exist in invertebrates, but which cells play this function in the insect retina is largely undefined. Using cell-restricted transc  ...[more]

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