Genomics

Dataset Information

0

Subpopulations of mouse beta cells


ABSTRACT: Type 1 diabetes (T1D) is a chronic autoimmune disease that involves immune mediated destruction of β cells. How β cells respond to immune attack is unknown. We identified a population of β cells during the progression of T1D in non-obese diabetic (NOD) mice that survives immune attack. This population develops from normal β cells confronted with islet infiltrates. Pathways involving cell movement, growth and proliferation, immune responses, and cell death and survival are activated in these cells. There is reduced expression of β cell identity genes and diabetes antigens and increased immune inhibitory markers and stemness genes. This new subpopulation is resistant to killing when diabetes is precipitated with cyclosphosphamide. Human β cells show similar changes when cultured with immune cells. These changes may account for the chronicity of the disease and the long term survival of β cells in some patients.

ORGANISM(S): Mus musculus

PROVIDER: GSE94382 | GEO | 2017/02/02

SECONDARY ACCESSION(S): PRJNA369532

REPOSITORIES: GEO

Similar Datasets

2019-03-29 | GSE128315 | GEO
2016-02-24 | PXD000859 | Pride
2021-02-11 | GSE166572 | GEO
| E-GEOD-55099 | biostudies-arrayexpress
2014-08-16 | GSE55099 | GEO
2024-01-01 | GSE228219 | GEO
| E-GEOD-55098 | biostudies-arrayexpress
| E-MEXP-3572 | biostudies-arrayexpress
2024-02-27 | GSE226361 | GEO
| E-MEXP-3235 | biostudies-arrayexpress