Ontology highlight
ABSTRACT:
INSTRUMENT(S): Ion Torrent Proton (Mus musculus)
ORGANISM(S): Mus musculus
SUBMITTER: Gergana Dobreva
PROVIDER: GSE94680 | GEO | 2019-04-15
REPOSITORIES: GEO
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GSE94680_Lmnb1_MLE12_RNA_seq_DEseq2_diffe_expression.xlsx | Xlsx | |||
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The Journal of experimental medicine 20190423 6
Although abnormal nuclear structure is an important criterion for cancer diagnostics, remarkably little is known about its relationship to tumor development. Here we report that loss of lamin B1, a determinant of nuclear architecture, plays a key role in lung cancer. We found that lamin B1 levels were reduced in lung cancer patients. Lamin B1 silencing in lung epithelial cells promoted epithelial-mesenchymal transition, cell migration, tumor growth, and metastasis. Mechanistically, we show that ...[more]