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Next Generation Sequencing Facilitates Quantitative Analysis of FoxO3 or Geminin/FoxO3 depletion on MDA-MB-231 cells Transcriptomes

ABSTRACT: We generated 2 Gb of high-quality sequencing data (~1 Gb per sample) and catalogued the expression profiles of 48,162 annotated human genes in each sample. The analysis showed differences of transcriptomes between Control and Geminin/FoxO3 co-depletion expression changes. We identified numerous differentially expressed genes that exhibited distinct expression patterns. These genes are appealing candidates for further investigation of the gene expression and associated regulatory mechanisms by Geminin and FoxO3 .

ORGANISM(S): Homo sapiens

PROVIDER: GSE94687 | GEO | 2017/08/22

SECONDARY ACCESSION(S): PRJNA371816

REPOSITORIES: GEO

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Next Generation Sequencing Facilitates Quantitative Analysis of Chenopodium quinoa Transcriptomes

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Next Generation Sequencing Facilitates Quantitative Analysis of seed development of Tartary buckwheat Transcriptomes

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Next Generation Sequencing Facilitates Quantitative Analysis of Seed Development of Easy Dehulling Tartary Buckwheat Transcriptomes

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Next Generation Sequencing Facilitates Quantitative Analysis of the control and H2O2-treated IMR90 cells Transcriptomes

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Geminin promoter occupancy and Geminin-dependent histone acetylation during neuroectodermal cell specification

Project description:The nucleoprotein Geminin (Gmnn) promotes neural cell fate acquisition of embryonic stem cells, while knockdown reduces the efficiency of neural gene activation. This occurs, at least in part, through Geminin’s ability to promote histone hyperacetylation at neural genes, to activate their expression. In mouse models in vivo, Geminin deficiency in the embryonic neural tube between embryonic days 8.5-10.5 also reduces the expression of genes controlling neural specification and/or differentiation, contributing to neural tube defects. To determine where Geminin binding and Gmnn-dependent acetylation occurs throughout the genome, we performed ChIP-chip analysis (these data) and ChIP-seq analysis (GSE77246) to define Geminin-bound chromatin locations in mouse embryonic stem cells (ESCs) and in ESC-derived neuroectoderm. We also performed ChIP-chip analysis of H3K9 acetylation in ESC-derived neuroectoderm, with or without Doxycycline-dependent Gmnn knockdown, to define the requirements for Geminin activity for histone acetylation of promoters during neural fate specification.

2016-12-01 | GSE81450 | GEO

Transcriptomic insight into molecular processes of dorsal muscle remodeling during Microhyla fissipes metamorphosis

Project description:We generated 120 Gb of raw sequencing data (~10 Gb per sample) and catalogued the expression profiles of 55106 annotated unigenes.We identified numerous differentially expressed genes that exhibited distinct expression patterns, and tight junction that were highly differentiated between S40 and S45, as well as between S36 and S43, S45. And genes related to glycolysis and pancreatic secretion were significantly enrichement beweent S43 and S45, these genes have known or potential roles in defense response and were enriched in functional gene categories potentially responsible for cucumber resistance.These results indicated that there are two process during metamorphosis, first one from S36-S43 is the larvel muscle development and apopsist, and the second from S43-S45 is the adult muscle development. Therefore, they are appealing candidates for further investigation of the gene expression and associated regulatory mechanisms related to muscle remodeling during metamorphosis.

2020-12-26 | GSE108552 | GEO

Geminin represses mesendoderm cell fate acquisition in embryoid bodies

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2014-07-01 | GSE39676 | GEO

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