Transcriptomics

Dataset Information

19

Gene expression profiling of metastatic and non-metastatic osteosarcoma biopsies


ABSTRACT: Osteosarcoma (OS) is the most common primary bone tumour in children and young adults, and the second highest cause of cancer-related death in this age group. In spite of aggressive chemotherapy, disease-free survival has not improved significantly in the past 20 years, and 50% of patients subsequently develop fatal pulmonary metastasis. We have performed gene expression profiling of primary osteosarcoma biopsies (i) to identify prognostic markers, and (ii) to identify novel therapeutic targets. Keywords: Comaprison between disease status (metastatic vs non-metastatic) and normal Overall design: Two-colour experiment. 7 samples for non-metastatic patients, 6 of which are analyzed in duplicate (dye-swaps); 11 samples for metastatic patients, 10 of which are analyzed in duplicate (dye-swaps); 5 samples of non-malignant bone analyzed individualy, no dye-swaps (i.e. 5 biological replicates).

INSTRUMENT(S): Agilent- Whole Human Genome Oligo Microarray G4112A condensed

ORGANISM(S): Homo sapiens  

SUBMITTER: Liliana Beatriz Endo-Munoz   

PROVIDER: GSE9508 | GEO | 2010-08-30

SECONDARY ACCESSION(S): PRJNA103301

REPOSITORIES: GEO

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