Genomics

Dataset Information

26

Gene expression analysis in rat liver after exposure to pregnenolone-16α-carbonitrile


ABSTRACT: RCCHanTM:WIST male rats were administered for 7 days by oral gavage with vehicle (corn oil) or 100 mg/kg/day of pregnenolone-16α-carbonitrile(PCN). We used microarrays to evaluate gene expression profiling in rat liver at the early phase of treatment with PCN. Overall design: After treatment periods, livers of 6 rats (3 rats in each group) were excised for RNA extraction and hybridization on Agilent microarrays.

INSTRUMENT(S): Agilent-028279 SurePrint G3 Rat GE 8x60K Microarray (Feature Number version)

SUBMITTER: Ayako Ohara 

PROVIDER: GSE95475 | GEO | 2018-10-10

REPOSITORIES: GEO

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Publications

Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile.

Nagahori Hirohisa H   Nakamura Kenji K   Sumida Kayo K   Ito Shingo S   Ohtsuki Sumio S  

Journal of proteome research 20170906 10


Transcriptomic, proteomic, phosphoproteomic, and metabolomic analyses were combined to determine the role of pregnane X receptor (PXR) in nongenotoxic signaling and energy homeostasis in liver after rats were repeatedly orally dosed with the PXR agonist pregnenolone carbonitrile (PCN) for 7 days. Analyses of mRNAs and proteins in the supernatant, membrane, and cytosolic fractions of enlarged liver homogenates showed diverse expression profiles. Gene set enrichment analysis showed that the synchr  ...[more]

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