Transcriptomics,Genomics

Dataset Information

25

Antidepressant actions of the exercise-regulated gene VGF


ABSTRACT: Gene profiling hippocampal mRNA from 1 week sedentary mice vs. 1 week voluntary exercise mice. Keywords: Exercise study. Overall design: Two-condition experiment, Sedentary vs. Exercise. Biological replicates: 4 sedentary, 4 exercise. One replicate per array.

INSTRUMENT(S): Yale/Duman cDNA spotted array

SUBMITTER: Joshua Hunsberger  

PROVIDER: GSE9565 | GEO | 2007-11-30

SECONDARY ACCESSION(S): PRJNA103385

REPOSITORIES: GEO

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Publications

Antidepressant actions of the exercise-regulated gene VGF.

Hunsberger Joshua G JG   Newton Samuel S SS   Bennett Alicia H AH   Duman Catharine H CH   Russell David S DS   Salton Stephen R SR   Duman Ronald S RS  

Nature medicine 20071202 12


Exercise has many health benefits, including antidepressant actions in depressed human subjects, but the mechanisms underlying these effects have not been elucidated. We used a custom microarray to identify a previously undescribed profile of exercise-regulated genes in the mouse hippocampus, a brain region implicated in mood and antidepressant response. Pathway analysis of the regulated genes shows that exercise upregulates a neurotrophic factor signaling cascade that has been implicated in the  ...[more]

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