Genomics

Dataset Information

31

Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals


ABSTRACT: Differential gene expression in mouse models of mitochondrial dysfunction Overall design: various mutants vs. wild type

INSTRUMENT(S): Illumina HiSeq 4000 (Mus musculus)

SUBMITTER: Irina Kuznetsova  

PROVIDER: GSE96518 | GEO | 2017-11-14

SECONDARY ACCESSION(S): PRJNA378878

REPOSITORIES: GEO

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Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals.

Kühl Inge I   Miranda Maria M   Atanassov Ilian I   Kuznetsova Irina I   Hinze Yvonne Y   Mourier Arnaud A   Filipovska Aleksandra A   Larsson Nils-Göran NG  

eLife 20171114


Dysfunction of the oxidative phosphorylation (OXPHOS) system is a major cause of human disease and the cellular consequences are highly complex. Here, we present comparative analyses of mitochondrial proteomes, cellular transcriptomes and targeted metabolomics of five knockout mouse strains deficient in essential factors required for mitochondrial DNA gene expression, leading to OXPHOS dysfunction. Moreover, we describe sequential protein changes during post-natal development and progressive OXP  ...[more]

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