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Functional diversified kaurene synthase like genes in Isodon rubescens shed light on chemical diversity evolution of diterpenoids in Lamiaceae

ABSTRACT: The Lamiaceae family contains numerous diterpenoids, offering a valuable model system for the study of diterpenoid chemical diversity. In this study we report that the ent-kaurene diterpenoids in I. rubescens have the largest diTPS gene family identified in Lamiaceae. Three genes are predicted to be involved in ent-kaurene diterpenoid synthesis while another two KSL genes are functional enzymes utilizing ent-CPP as a substrate. We also showed the presence of a normal-CPP mediated biosynthesis pathway in I. rubescens and that three KSL genes possessing different domain architectures are involved in this pathway. This study provides new information regarding the understanding of diterpenoid chemical diversity and this compounds’ evolution in the Lamiaceae family. Overall design: RNA-seq of Isodon rubescens leaf tissue in Spring

INSTRUMENT(S): Illumina HiSeq 2000 (Isodon rubescens)

ORGANISM(S): Isodon Rubescens

SUBMITTER: Tong Chen  

PROVIDER: GSE96954 | GEO | 2017-09-08



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Functional Diversification of Kaurene Synthase-Like Genes in <i>Isodon rubescens</i>.

Jin Baolong B   Cui Guanghong G   Guo Juan J   Tang Jinfu J   Duan Lixin L   Lin Huixin H   Shen Ye Y   Chen Tong T   Zhang Huabei H   Huang Luqi L  

Plant physiology 20170405 2

<i>Ent</i>-kaurene diterpenoids are the largest group of known <i>Isodon</i> diterpenoids. Among them, oridonin is accumulated in the leaves, and is the most frequently studied compound because of its antitumor and antibacterial activities. We have identified five copalyl diphosphate synthase (CPS) and six kaurene synthase-like (KSL) genes by transcriptome profiling of <i>Isodon rubescens</i> leaves. An in vitro assay assigns ten of them to five different diterpene biosynthesis pathways, except  ...[more]

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