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Epididymal adipose tissue gene expression in wildtype mice and mice with inactivated mesoderm specific transcript

ABSTRACT: The goal of this study is to compare transcriptome profiles of epididymal adipose tissue from wildtype mice and mice with a targeted inactivation of mesoderm specific transcript (Mest) fed a high fat diet from 8 to 16 weeks of age to gain insight for MEST function. Gene expression profiling resulted in relatively few changes (~36 targets; FDR padj<0.1) in gene expression in epididymal WAT from wildtype mice and mice with inactivated paternal allele for Mest. A less stringent analyses of the dataset (P ≤ 0.05; with mean of ≥ 50 sequence tags for at least one group) identified 395 genes more highly expressed in epididymal adipose tissue of wildtype mice and 301 genes more highly expressed in mice with a paternal inactivation of Mest. Gene pathway analyses of differentially expressed genes showed decreased expressed of genes associated with immune response and inflammation in high fat diet-fed mice with inactivated Mest compared with wildtype mice. Transcritome analyses supported phenotypic measurements which indicated improved glucose homeostasis in mice with inactivated Mest.

ORGANISM(S): Mus musculus

PROVIDER: GSE96968 | GEO | 2017/08/17

SECONDARY ACCESSION(S): PRJNA380237

REPOSITORIES: GEO

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